過去瑞德西韋(remdesivir)的跨國研究就曾發現,亞洲人的治療效果最差
面對變種病毒Delta,以色列推行開打BNT疫苗第三劑,目前只要是四十歲以上的國民或者有有特殊疾病者都可以接種第三劑疫苗,目前已經有超過200萬的國民接種第三劑疫苗。
不管WHO的反對,美國與許多歐洲國家也同步計畫第三劑疫苗的接種計畫!
疫情期間最困擾的一個問題就是,孩子的教育怎麼辦?到學校會不會增加被傳染的機會?
各學校寄出各種防疫措施,到底有多少效果仍然是未知.....
最近瑞士完成教室防疫研究,探討如何可以讓教室中的懸浮病毒減少!
COVID-19留下的肺損傷,毛玻璃狀變化(GGO) 會消失,但是肺纖維化會留下來!
以色列疫情風暴再起!科學家找到可能的原因了!
以色列是世界上COVID-19疫苗施打最快速的國家,六成國民施打完整兩劑的RNA疫苗,但是以色列最近仍然疫情失控,讓人不禁好奇到底原因是什麼?
https://www.medrxiv.org/content/10.1101/2021.08.24.21262415v1最近一篇以色列科學家的研究發現,疫苗引起的保護力與感染後產生的保護力居然有很大的差異!
以色列是世界上COVID-19疫苗施打最快速的國家,六成國民施打完整兩劑的疫苗,但是以色列最近仍然疫情失控,讓人不禁好奇到底原因是什麼?
https://www.medrxiv.org/content/10.1101/2021.08.19.21262111v1
最近一篇以色列科學家的研究發現,抗體濃度降低可能是重要的關鍵!
https://www.ndm.ox.ac.uk/covid-19/covid-19-infection-survey/results/new-studies
最近牛津大學研究團隊分析了英國2020年12月到2021年五月的疫情,並且比較每個人打的疫苗,並且比較各個疫苗對於變種病毒的防護能力。
而研究發現施打完整兩劑疫苗後,BNT的保護力略高於AZ疫苗,但是BNT的保護力下降的速度則較快!(原文:The dynamics of immunity following second doses differed significantly between BNT162b2 and ChAdOx1, with greater initial effectiveness against new PCR-positives but faster declines in protection against high viral burden and symptomatic infection with BNT162b2.)
在Delta病毒肆虐的現在,很多人關心打完疫苗是否可以減少病毒的肆虐!而美國衛斯康辛州的研究帶來壞消息,研究發現:打完兩劑完整疫苗的人感染仍然會帶一樣多的病毒。
https://www.medrxiv.org/content/10.1101/2021.07.31.21261387v3.full-text
07/26 重量級醫學期刊Nature Medicine又發文支持AZ與RNA疫苗混打
https://www.nature.com/articles/s41591-021-01463-x
文中提到的結論是:單用AZ疫苗抗體弱、T細胞免疫強;單用mRNA疫苗抗體強、T細胞免疫弱;而混打則可以抗體與T細胞免疫兩樣都強!!
Delta變種病毒快速蔓延,Delta變異株(最先在印度發現)目前已是全球COVID-19最主要的流行病毒株,大家都想知道到底疫苗對Delta變異株到底有沒有效果!?
今天NEJM刊登來自英國的大規模施打研究分析了,打BNT疫苗與AZ疫苗對 Alpha與Delta變種病毒的效果!
對Delta病毒完整接種BNT疫苗防護力88%,AZ疫苗67%!!
自從疫苗上市之後,許多學者與媒體都喜歡將疫苗排名次!
而一般來說大家常常把mRNA疫苗中的BNT輝瑞與Moderna擺在榜首的位置!
不過最近來自英國的真實世界研究發現,英國人民施打BNT與AZ疫苗的效果是相同的!
結果發現AZ混打莫德納比起AZ兩劑,中和抗體濃度能增加十倍以上!!
而副作用雖然有增加,沒有統計學上有意義的增加!
https://www.nejm.org/doi/full/10.1056/NEJMc2110716
⭐七月八日的NEJM新聞提醒大家,COVID-19的痊癒者接種mRNA疫苗,血中的中和抗體可以提升一百倍!
https://www.jwatch.org/na53802/2021/07/08/people-with-past-covid-19-benefit-immunization
「網路溫度計」
https://www.businessweekly.com.tw/focus/blog/3006651
COVID-19本土疫情升溫,確診數連日破百,各地醫療量能吃緊,在這個非常時期,醫護人員為了守護全台灣人的安全,冒著染疫風險站在前線,承受巨大無比的壓力。
今天《DailyView網路溫度計》透過《KEYPO大數據關鍵引擎》調查,本土疫情爆發後,網友熱議哪些「前線醫護」,及這些醫護人員看見了哪些醫療現場,身為一般民眾的我們,能做的就是遵守防疫規定,勤洗手、戴口罩、盡可能減少外出機會,在接受治療時,多給醫護人員耐心,齊心共度這次難關。
NO. 1 蘇一峰
市立聯合陽明醫院胸腔內科醫師蘇一峰,在急診室支援前線,揭露醫療量能的不足,讓許多人看見第一線人員的無奈與辛酸。
蘇一峰醫師指出,急診一班12小時,要為上百人快篩、插管急救,他穿著密不透風的隔離衣,汗水不斷滲濕衣褲,還要應付因久候篩檢而對急診醫護發脾氣的民眾,讓網友心疼表示「真的是刁民」、「沒有接觸史也沒有症狀的人就不要去快篩了,避免浪費醫療資源」。
分析說明:
本研究資料由《KEYPO大數據關鍵引擎》提供,分析時間範圍為2021年05月17日至2021年05月27日,共十天。
系統觀測上萬個網站頻道,包括各大新聞頻道、社群平台、討論區及部落格等,針對討論『醫護人員』相關文本進行分析,並根據網友就該議題之討論,作為本分析依據。
本文所調查之結果,非參考投票、民調、網路問卷等資料,名次僅代表網路討論聲量大小,不代表網友正負評價。
(圖片來自武漢醫院紀錄照片 https://www.sixthtone.com/news/1005551/snapshots-of-a-wuhan-icu)
COVID-19的重症病人比一般非COVID的病人有較高的死亡率,研究發現COVID-19病人當心跳停止時就算接受急救,絕大部分仍然會走向死亡!!
台灣2021年疫情爆發期間,分別傳出好幾起感染者在家死亡的案子!
新增死亡案例!永和78歲確診男家中無呼吸送醫不治 發布 2021.05.21 | 21:31
70歲染疫婦「拒絕就醫」死在家中!失聯3日今確診 2021-05-20 15:44 聯合報
Silent Hypoxia「沉默低血氧」 或 Happy Hypoxia「快樂低血氧」這個名詞早在2020年的4-5月就有英文文獻可查,COVID-19的病人常常會出現身體已經有低血氧的情形,但是患者卻沒有出現呼吸困難的感覺,也因此容易耽誤就醫延誤病情,更可能造成突然猝死的情形!
中國在面對美國的大國競爭之下,訂定下一個五年計劃要全力發展自己的基礎科學研發能力!
中國決定投入更多的研發資金到科學研究當中,2021年將增加更多資金投入基礎研究當中!
而Nature 專文評論這件事,卻指出了中國論文造假工廠可能是最大的問題 https://www.nature.com/articles/d41586-021-00638-3According to the five-year plan, China intends to increase spending on research and development (R&D) by more than 7% annually.
Li said that central-government spending on basic research would also increase, by 10.6% in 2021, which Cong says is higher than the average annual increase over the past five years. And the plan proposes raising the overall share of basic research in R&D spending from 6% to more than 8%. Although that increase is welcome, it would still be only half the proportion of R&D spending of many countries, says Cong. The United States, for example, currently spends about 17% of R&D funding on basic research.
More details on China’s science funding are scheduled to emerge later this year.
The pressure to meet societal goals and the competitive system for disseminating funding could also result in researchers cheating the system in new ways. “The tolerance for failure is going to be low,” says Zhang. And with fewer scientific publications as a result of the shift to industry, Chinese scientists’ work will become less visible to the world, she says. “They are pushing elite scientists into a dark room behind closed doors.”
Nature專家指出中國論文工廠造假論文嚴重,Nature發現中國製造的造假論文光2020年,一年被撤回三百七十篇,而其中一千多篇有學術上的疑雲.....而撤回論文其中的197篇是來自於中國的醫院。
(https://www.nature.com/articles/d41586-021-00733-5)
Publishers almost never explicitly declare on retraction notices that a particular study is fraudulent or was created by a company to order, because it is difficult to prove. None of the RSC’s retraction notices, for instance, mentions a paper mill — despite the RSC’s announcement that it thinks the articles did come from one. But Nature has tallied 370 articles retracted since January 2020, all from authors at Chinese hospitals, that either publishers or independent sleuths have alleged to come from paper mills (see ‘Fraud allegations’). Most were published in the past three years (see ‘Chinese hospital papers on the rise’). Publishers have added expressions of concern to another 45 such articles.
Nature has identified a further 197 retractions of papers from authors at Chinese hospitals since the start of last year. These are not ones that have made it onto lists of potential publication-mill products, although some were flagged by sleuths for image concerns, often on the post-publication peer-review website PubPeer.
中國醫院為何大量製造假論文成為論文工廠的最大客戶呢?
因為中國的大醫院規定要成為主任級醫師必須有論文發表,而這些醫師大多忙於臨床沒有時間做研究,但是為了在醫院順利升等升官就要生出論文。於是此時論文工廠就是他們的救命繩索。
Nature期刊則發專文檢討這些亂象,並認為中國需要檢討如何讓提昇論文的可靠性
Five ways China must cultivate research integrity (中國必須培養研究誠信的五種方式)
Publishers and others battling paper mills suspect they are only seeing the tip of the iceberg in the published literature. In part, that’s because similarities between images across studies might become obvious only when many papers are compared. Sleuths also know that features such as similar western blots and flawed nucleotide sequences might be the most obvious signs of paper-mill activity, says Bik. “There may be tonnes of other paper mills that have done a better job of hiding it,” she says. Editors at the COPE forum said they’d seen paper mills in areas such as computer sciences, engineering, humanities and social sciences, for instance.
The overall size of the paper-mill problem probably runs to thousands or tens of thousands of papers, Bik, Byrne and others think. Graf, at Wiley, says it’s hard to estimate. “I don’t think it should be understated, I can’t say how big it is,” he says. “We have very little information about the people or companies doing this. I am exasperated by the situation, and that is being polite.”
當然過去中國政府已經做了許多打擊假論文的法規!不過Nature仍然擔心未來在中國拿出更多經費投入科學研發的同時,會有更多論文工廠提供的假研究論文會更嚴重。
而令人高興的是AZ疫苗,對於重症的保護力高達100%!!
北區一名30歲的男子過去抽傳統香菸十年,在朋友的介紹之下開始使用電子煙,使用幾個月後開始出現咳嗽又喘痰多呼吸不暢,除了呼吸道的問題之外,還出現全身性的抓癢脫屑
之後這名男子多次住院因為氣喘發作與皮膚脫屑脫皮,使用類固醇之後病情略微改善後出院,但是因為持續使用電子煙,氣喘反覆發作皮膚也越來越嚴重.............