Nature:打完疫苗為何還是會被感染COVID-19？NEJM研究揭密，原因在於抗體濃度低！！

 

7/29 Nature的新聞提出了一個大家都好奇的討論，為什麼人打完疫苗為何還是會被感染COVID-19？

這篇Nature新聞引用了一篇研究，該研究於 7 月 28 日發表在《新英格蘭醫學雜誌NEJM》上，該研究借鑒了以色列特拉維夫接近 11,500 名完全接種兩劑BNT疫苗的醫護人員的數據。 

2021 年 1 月至 4 月之間的廣泛病毒檢查測試發現了 39 名醫護人院儘管已經接種了疫苗，但仍感染了 SARS-CoV-2，所有感染者是輕微症狀或根本沒有症狀。

 

研究對於被感染的 39 名醫護中的 22 名，獲得在感染當天或前一周進行的抗體測量。

研究分析後發現感染者的中和抗體水平較低，只有沒感染者1/3而已！

打完疫苗之後，正常沒感染者的保護抗體是被感染者的三倍！也因此打疫苗後產生的高濃度的抗體保護人類不受感染COVID-19！ 

 

AZ疫苗也發表過一樣的研究結果！抗體越高保護力也越高！

Results Higher levels of all immune markers were correlated with a reduced risk of symptomatic infection. Vaccine efficacy of 80% against primary symptomatic COVID-19 was achieved with an antibody level of 40923 (95% CI: 16748, 125017) and 63383 (95% CI: 16903, not computed (NC)) for anti-spike and anti-RBD, and 185 (95% CI: NC, NC) and 247 (95% CI: 101, NC) for pseudo- and live-neutralisation assays respectively. Antibody responses did not correlate with overall protection against asymptomatic infection.

https://www.medrxiv.org/content/10.1101/2021.06.21.21258528v1 

 

Nature新聞作者引用上面一篇AZ疫苗研究，認為AZ疫苗也可以一樣解釋，原文如下

"The results bolster earlier data collected during clinical trials of the Oxford–AstraZeneca vaccine. Analysis of those data also showed a link between higher levels of neutralizing antibodies and a lower likelihood of breakthrough infection2. But the difference in antibody levels between trial participants who had breakthrough infections and those who didn’t was not statistically significant."

 

打完疫苗抗體濃度越高，保護力就越高！這句話是真的！