2021年3月28日 星期日

中國宣布增加科學研發資金對抗美國競爭!但Nature說:造假研究論文恐怕要更多了....

中國在面對美國的大國競爭之下,訂定下一個五年計劃要全力發展自己的基礎科學研發能力!

中國決定投入更多的研發資金到科學研究當中,2021年將增加更多資金投入基礎研究當中!

而Nature 專文評論這件事,卻指出了中國論文造假工廠可能是最大的問題 https://www.nature.com/articles/d41586-021-00638-3

According to the five-year plan, China intends to increase spending on research and development (R&D) by more than 7% annually.

Li said that central-government spending on basic research would also increase, by 10.6% in 2021, which Cong says is higher than the average annual increase over the past five years. And the plan proposes raising the overall share of basic research in R&D spending from 6% to more than 8%. Although that increase is welcome, it would still be only half the proportion of R&D spending of many countries, says Cong. The United States, for example, currently spends about 17% of R&D funding on basic research.

More details on China’s science funding are scheduled to emerge later this year.

The pressure to meet societal goals and the competitive system for disseminating funding could also result in researchers cheating the system in new ways. “The tolerance for failure is going to be low,” says Zhang. And with fewer scientific publications as a result of the shift to industry, Chinese scientists’ work will become less visible to the world, she says. “They are pushing elite scientists into a dark room behind closed doors.”

Nature專家指出中國論文工廠造假論文嚴重,Nature發現中國製造的造假論文光2020年,一年被撤回三百七十篇,而其中一千多篇有學術上的疑雲.....而撤回論文其中的197篇是來自於中國的醫院。

(https://www.nature.com/articles/d41586-021-00733-5

Publishers almost never explicitly declare on retraction notices that a particular study is fraudulent or was created by a company to order, because it is difficult to prove. None of the RSC’s retraction notices, for instance, mentions a paper mill — despite the RSC’s announcement that it thinks the articles did come from one. But Nature has tallied 370 articles retracted since January 2020, all from authors at Chinese hospitals, that either publishers or independent sleuths have alleged to come from paper mills (see ‘Fraud allegations’). Most were published in the past three years (see ‘Chinese hospital papers on the rise’). Publishers have added expressions of concern to another 45 such articles.

Nature has identified a further 197 retractions of papers from authors at Chinese hospitals since the start of last year. These are not ones that have made it onto lists of potential publication-mill products, although some were flagged by sleuths for image concerns, often on the post-publication peer-review website PubPeer.

中國醫院為何大量製造假論文成為論文工廠的最大客戶呢?

因為中國的大醫院規定要成為主任級醫師必須有論文發表,而這些醫師大多忙於臨床沒有時間做研究,但是為了在醫院順利升等升官就要生出論文。於是此時論文工廠就是他們的救命繩索。


而中國醫院因此大量發表許多論文,而其中的部分論文則使用的是造假的資料.....

Nature期刊則發專文檢討這些亂象,並認為中國需要檢討如何讓提昇論文的可靠性

Five ways China must cultivate research integrity (中國必須培養研究誠信的五種方式)

Publishers and others battling paper mills suspect they are only seeing the tip of the iceberg in the published literature. In part, that’s because similarities between images across studies might become obvious only when many papers are compared. Sleuths also know that features such as similar western blots and flawed nucleotide sequences might be the most obvious signs of paper-mill activity, says Bik. “There may be tonnes of other paper mills that have done a better job of hiding it,” she says. Editors at the COPE forum said they’d seen paper mills in areas such as computer sciences, engineering, humanities and social sciences, for instance.

The overall size of the paper-mill problem probably runs to thousands or tens of thousands of papers, Bik, Byrne and others think. Graf, at Wiley, says it’s hard to estimate. “I don’t think it should be understated, I can’t say how big it is,” he says. “We have very little information about the people or companies doing this. I am exasperated by the situation, and that is being polite.”


當然過去中國政府已經做了許多打擊假論文的法規!不過Nature仍然擔心未來在中國拿出更多經費投入科學研發的同時,會有更多論文工廠提供的假研究論文會更嚴重。

2021年3月27日 星期六

Nature期刊兩篇新聞稿替AZ疫苗效果掛保證!

科學權威期刊<Nature自然>在3/25日發布了一則新聞,裡面公布了AZ疫苗最新的第三期研究結果,這個第三期研究分別在美國,智利和秘魯收案超過32000人,研究分析發現AZ疫苗對於感染的保護力為76%。

而令人高興的是AZ疫苗,對於重症的保護力高達100%!! 

2021年3月24日 星期三

COVID-19疫苗的保護力比一比

 


💥目前臨床研究的疫苗效力統整比較圖!!
(參考資料以臨床試驗結果為主!)
😢看起來南非變種病毒最麻煩,會大大影響疫苗的保護力......
 
目前這個表還沒有整理中國疫苗的保護效果,台灣國產疫苗的效果也還不知道

2021年3月16日 星期二

北區一男子身染怪病又咳又喘全身嚴重皮膚癢和脫皮,病因疑似是電子煙引起過敏反應!

北區一名30歲的男子過去抽傳統香菸十年,在朋友的介紹之下開始使用電子煙,使用幾個月後開始出現咳嗽又喘痰多呼吸不暢,除了呼吸道的問題之外,還出現全身性的抓癢脫屑

之後這名男子多次住院因為氣喘發作與皮膚脫屑脫皮,使用類固醇之後病情略微改善後出院,但是因為持續使用電子煙,氣喘反覆發作皮膚也越來越嚴重.............

 




2021年3月9日 星期二

千萬不要以為 "X光正常就等於沒有肺癌!"



😶一位六十多歲的大哥一進門診就說:「我今天不是來看病的」

「#我來謝謝您救我一命!」

💥病人三年前,蘇醫師安排做了LDCT低劑量電腦斷層,發現了兩個肺結節一個2.5公分,一個1.5公分!

💥蘇醫師馬上轉到北榮胸腔外科主任去開刀,胸外主任跟大哥說:「哪個內科醫生這麼厲害?幫你找到這兩個結節!蘇醫師喔,他很厲害!」

#兩顆結節開刀開下來都是肺腺癌.....!
「你再晚半一年開刀就來不及了!」
「蘇醫師救了你一命!」
肺部之後追蹤兩年沒有復發!

大哥:我今天特別來跟蘇醫師您說謝謝!讓從死神逃過一劫了!

#很多肺結節長到兩公分_X光仍然看不見喔!



面對早期肺癌來說、胸部X光不是一個足夠敏感的檢查工具,因為只能發現大於1-2公分以上的肺癌

而且肺癌還不能躲在死角位置! (如果肺癌躲在骨頭、心臟大血管或橫膈..等等器官的後面,則容易被擋住看不見)


所以大家千萬不要以為:胸部X光正常就等於沒有肺癌喔!

臨床上不少患者照X光正常,之後不久發生末期肺癌喔!

<<真實案例分享>>
案例一:一名四十多歲的家庭主婦,陪咳嗽不止的先生來門診檢查,太太自己不菸不酒會煮菜,自己也有一點點偶爾咳嗽,胸部X光完全正常。

聽完我的解釋後決定做個電腦斷層檢查,結果先生沒事,太太發現到1.5公分的肺腺癌!目前開完刀救回一命。





案例二:門診一位50歲的中年女性不菸不酒,也沒有煮菜油煙與二手菸的暴露,最近三個月走路感覺略喘,在先生的積極勸說下,終於來胸腔科的門診看病

但是沒想到X光一照發現已經是末期肺癌了.....
患者得知噩耗之後,崩潰的想問兩個問題:
一、為何一年多前的胸腔X光報告還正常,今年的胸腔X光就被宣判是絕症(肺癌末期)!?!!而且她只有輕微喘的症狀,就已經是肺癌末期!
二、患者一輩子不菸不酒,也不煮菜接觸油煙,為何肺癌會選上她!

2021年3月8日 星期一

最新全世界2019十大死因公佈了!中風、肺阻塞COPD、肺癌死亡人數持續增加

在2020年的12月,世界衛生組織WHO公布了全世界的十大死因排行榜,分別是:缺血心臟病、中風、肺阻塞(慢性阻塞性肺病COPD)、下呼吸道感染(肺炎)、新生兒死亡、肺癌、失智症、腹瀉、糖尿病與腎臟病。

其中中風、COPD與肺癌都是持續增加的成人死亡原因,而新生兒死亡是第一次歸類上榜的死因。